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BRAINSTORMS
Clinical Neuroscience Updates
by
Stephen M. Stahl, M.D., Ph.D.


In collaboration with The Journal of Clinical Psychiatry
Brainstorms, published monthly by The Journal of Clinical Psychiatry, aim to provide updates of novel concepts emerging from neurosciences that have relevance to the practicing psychiatrist. Selected articles of particular interest to the treatment of depression will be reproduced on depression-webworld.com on a regular basis.

IMPORTANT ANNOUNCEMENT

After producing Brainstorm articles every month for many years, Professessor Stephen Stahl, has decided to stop this feature to enable him to concentrate on other projects as described on the website of his institute

Depression-Webworld can, therefore, no longer update this feature although the Brainstorm articles currently on the site will remain available (see below).

April 2005


Brainstorms available:

1. Are two antidepressant mechanisms better than one?

2. The psychopharmacology of painful physical symptoms in depression?

3. Blue genes and the monoamine hypothesis of depression

4. Blue genes and the mechanism of action of antidepressants

5. The 7 habits of highly effective psychopharmacologists - Part 1. Overview

6. The 7 habits of highly effective psychopharmacologists - Part 2. Begin with the end in mind

7. The 7 habits of highly effective psychopharmacologists - Part 3. Sharpen the saw with selective choices of continuing medical education programs

8. The 7 habits of highly effective psychopharmacologists - Part 4. Developing and implementing the vision

9. The psychopharmacology of energy and fatigue

10. Awakening to the psychopharmacology of sleep and arousal:
Novel Neurotransmitters and Wake-promoting Drugs

11. Psychopharmacology of wakefulness: Pathways and neurotransmitters

12. Mergers and acquisitions among psychotropics: Antidepressant takeover of anxiety may now be complete

13. Does evidence from clinical trials in psychopharmacology apply in clinical practice?

14. Effects of estrogen on the central nervous system

15. Natural estrogen as an antidepressant for women

16. Why settle for silver, when you can go for gold? Response vs. recovery as the goal of antidepressant therapy

17. Antidepressants: The blue-chip psychotropic for the modern treatment of anxiety disorders

18. Antidepressants and somatic symptoms: Therapeutic Actions Are Expanding Beyond Affective Spectrum Disorders to Functional Somatic Syndromes

19. Molecular neurobiology for practicing psychiatrists - Part 1.
Overview of Gene Activation by Neurotransmitters

20. Molecular neurobiology for practicing psychiatrists - Part 2.
How Neurotransmitters Activate Second Messenger Systems

21. Molecular neurobiology for practicing psychiatrists - Part 3.
Second Messengers “Turn On” Genes by Activating Protein Kinases and Transcription Factors

22. Molecular neurobiology for practicing psychiatrists - Part 4.
Transferring the Message of Chemical Neurotransmission From Presynaptic Neurotransmitter to Postsynaptic Gene Expression

23. Molecular neurobiology for practicing psychiatrists, Part 5.
How a Leucine Zipper Can Turn On Genes: Immediate-Early Genes Activate Late-Gene Expression in the Brain

24. Here today and not gone tomorrow: The Curse of Chronic Pain and Other Central Sensitization Syndromes

25. The psychopharmacology of sex, Part 1. Neurotransmitters and the 3 Phases of the Human Sexual Response

26. The psychopharmacology of sex, Part 2. Effects of Drugs and Disease on the 3 Phases of Human Sexual Response

27. Deconstructing psychiatric disorders, Part 1. Genotypes, Symptom Phenotypes, and Endophenotypes

28. Deconstructing psychiatric disorders, Part 2. An Emerging, Neurobiologically Based Therapeutic Strategy for the Modern Psychopharmacologist

29. Symptoms and circuits, Part 1. Major Depressive Disorder

30. Symptoms and circuits, Part 2. Anxiety Disorders

31. Neurotransmission of cognition, Part 1. Dopamine Is a Hitchhiker in Frontal Cortex: Norepinephrine Transporters Regulate Dopamine

32. Neurotransmission of cognition, Part 2. Selective NRIs Are Smart Drugs: Exploiting Regionally Selective Actions on Both Dopamine and Norepinephrine to Enhance Cognition

33. Neurotransmission of cognition, Part 3. Mechanism of Action of Selective NRIs: Both Dopamine and Norepinephrine Increase in Prefrontal Cortex

34. Does depression hurt?

35. Fibromyalgia: The Enigma and the Stigma

36. Gut Feelings about Irritable Bowel Syndrome

37. Don’t ask, don’t tell, but benzodiazepines are still the leading treatments for anxiety disorder

38. Independent actions on fear circuits may lead to therapeutic synergy for anxiety when combining serotonergic and GABAergic agents

39. Anticonvulsants as Anxiolytics, Part 1: Tiagabine and Other Anticonvulsants With Actions on GABA

40. Anticonvulsants as Anxiolytics, Part 2: Pregabalin and Gabapentin as alpha-2-delta Ligands at Voltage-Gated Calcium Channels

41. Drug Combinations for Bipolar Spectrum Disorders: Evidence-Based Prescribing or Prescribing-Based Evidence?

42. Mental Illness May Be Damaging to Your Brain

43. At Long Last, Long-Lasting Psychiatric Medications: An Overview of Controlled-Release Technologies

44. Anticonvulsants as Mood Stabilizers and Adjuncts to Antipsychotics: Valproate, Lamotrigine, Carbamazepine, and Oxcarbazepine and Actions at Voltage-Gated Sodium Channels

45. Anticonvulsants and the Relief of Chronic Pain: Pregabalin and Gabapentin as a2d Ligands at Voltage-Gated Calcium Channels

46. Preemptive Analgesia: Is Pain Less Costly When You Pre-Pay For It?

47. Mirror, Mirror on the Wall, Which Enantiomer Is Fairest of Them All?

Brainstorm articles: Copyright © The Journal of Clinical Psychiatry


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Updated April 2005

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